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    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/119979

    Title: Assessment of the efficacy of intra-articular platelet rich plasma treatment in an ACLT experimental model by dynamic contrast enhancement MRI of knee subchondral bone marrow and MRI T2∗ measurement of articular cartilage
    Authors: Guo-Shu Huang;Yi-Jen Peng;Dennis W. Hwang;Herng-Sheng Lee;Yue-Cune Chang;Shih-Wei Chiang;Yi-Chih Hsu;Ying-Chun Liu;Ming-Huang Lin;Chao-Ying Wang
    Keywords: Subchondral bone vascularization;Platelet rich plasma;Osteoarthritis;Anterior cruciate ligament transection;Dynamic contrast enhanced MRI;MRI T2*
    Date: 2021-02-10
    Issue Date: 2021-02-25 12:10:45 (UTC+8)
    Abstract: Objective: The vascularization of subchondral bone plays a significant role in the progression of knee
    osteoarthritis (OA). Treatment with platelet-rich plasma (PRP) has positive effects on cartilage lesions.
    However, PRP's efficacy for subchondral bone marrow lesions and the relationship of these lesions to
    cartilage are still undiscovered. Therefore, our aims were first to longitudinally investigate the change in
    subchondral flow by dynamic contrast enhanced MRI and degeneration of cartilage by MRI T2* in an
    anterior cruciate transection rodent (ACLT) model, and second to examine changes in parameters after
    intra-articular PRP injection.
    Design: A 32-week investigation in 18 rats allocated to sham-control, ACLT with normal saline injection
    (ACLT þ NS), and ACLT with PRP injection groups ended with histological evaluation. Another rat was
    used as a donor of allogenic PRP.
    Results: Compared to the sham-control group, the ACLT þ NS group had higher subchondral blood
    volume A (0.051, 95% confidence interval: 0.009, 0.092) and lower venous washout kel
    (0.030: 0.055, 0.005) from week 4; lower permeability kep from week 18 (0.954: 1.339, 0.569);
    higher cartilage T2* values (1.803: 1.504, 2.102) reflecting collagen loss beginning at week 10. For the PRP
    treatment group, subchondral bone marrow A and cartilage T2* decreased from week 10. Histological
    results confirmed and were correlated with the MRI findings.
    Conclusion: Subchondral hyper-perfusion plays a vital role in the pathogenesis of OA and was associated
    with cartilage degeneration. The efficacy of PRP can be observed from reduced perfusion and MRI T2*
    Relation: Osteoarthritis and Cartilage 29(5), p.718-727
    DOI: https://doi.org/10.1016/j.joca.2021.02.001
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

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