淡江大學機構典藏:Item 987654321/119976
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    題名: Genome-Wide and Candidate Gene Association Analyses Identify a 14-SNP Combination for Hypertension in Patients With Type 2 Diabetes
    作者: Chi-Fung Cheng;Ai-Ru Hsieh(謝璦如);Wen-Miin Liang;Ching-Chu Chen;Chien-Hsiun Chen;Jer-Yuarn Wu;Ting-Hsu Lin;Chiu-Chu Liao;Shao-Mei Huang;Yu-Chuen Huang;Bo Ban;Ying-Ju Lin;Fuu-Jen Tsai
    關鍵詞: genetic SNP;biomarker;genetic risk score;hypertension;type 2 diabetes
    日期: 2020-12-04
    上傳時間: 2021-02-25 12:10:22 (UTC+8)
    摘要: Background
    High blood pressure is common and comorbid with type 2 diabetes (T2D). Almost 50% of patients with T2D have high blood pressure. Patients with both conditions of hypertension and T2D are at risk for cardiovascular diseases and mortality. The study aim was to investigate genetic risk factors for hypertension in T2D patients.

    Methods
    This study included 999 T2D (cohort 1) patients for the first genome scan stage and 922 T2D (cohort 2) patients for the replication stage. Here, we investigated the genetic susceptibility and cumulative weighted genetic risk score for hypertension in T2D patients of Han Chinese descent in Taiwan.

    Results
    Thirty novel genetic single nucleotide polymorphisms (SNPs) were associated with hypertension in T2D after adjusting for age and body mass index (p-value < 1 x10 -4). Eight blood pressure-related and/or hypertension-related genetic SNPs were associated with hypertension in T2D after adjusting for age and body mass index (p-value < 0.05). Linkage disequilibrium (LD) and cumulative weighted genetic risk score analyzes showed that 14 of the 38 SNPs were associated with risk of hypertension in a dose-dependent manner in T2D (Cochran-Armitage trend test: p-value < 0.0001). The 14-SNPs cumulative weighted genetic risk score was also associated with increased regression tendency of systolic blood pressure in T2D (SBP = 122.05 + 0.8 x weighted GRS; p-value = 0.0001).

    Conclusions
    A cumulative weighted genetic risk score composed of 14 SNPs is important for hypertension, increased tendency of systolic blood pressure, and may contribute to hypertension risk in T2D in Taiwan.
    關聯: AMERICAN JOURNAL OF HYPERTENSION 34(6), p.651-661
    DOI: 10.1093/ajh/hpaa203
    顯示於類別:[統計學系暨研究所] 期刊論文

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