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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/119976


    Title: Genome-wide and candidate gene association analyses identify a 14-SNPs combination for hypertension in patients with type 2 diabetes
    Authors: Cheng, Chi-Fung;Hsieh, Ai-Ru;Liang, Wen-Miin;Chen, Ching-Chu;Chen, Chien-Hsiun;Wu, Jer-Yuarn;Lin, Ting-Hsu;Liao, Chiu-Chu;Huang, Shao-Mei;Huang, Yu-Chuen;Ban, Bo;Lin, Ying-Ju;Tsai, Fuu-Jen
    Keywords: genetic SNP;biomarker;genetic risk score;hypertension;type 2 diabetes
    Date: 2020-12-04
    Issue Date: 2021-02-25 12:10:22 (UTC+8)
    Abstract: Background
    High blood pressure is common and comorbid with type 2 diabetes (T2D). Almost 50% of patients with T2D have high blood pressure. Patients with both conditions of hypertension and T2D are at risk for cardiovascular diseases and mortality. The study aim was to investigate genetic risk factors for hypertension in T2D patients.

    Methods
    This study included 999 T2D (cohort 1) patients for the first genome scan stage and 922 T2D (cohort 2) patients for the replication stage. Here, we investigated the genetic susceptibility and cumulative weighted genetic risk score for hypertension in T2D patients of Han Chinese descent in Taiwan.

    Results
    Thirty novel genetic single nucleotide polymorphisms (SNPs) were associated with hypertension in T2D after adjusting for age and body mass index (p-value < 1 x10 -4). Eight blood pressure-related and/or hypertension-related genetic SNPs were associated with hypertension in T2D after adjusting for age and body mass index (p-value < 0.05). Linkage disequilibrium (LD) and cumulative weighted genetic risk score analyzes showed that 14 of the 38 SNPs were associated with risk of hypertension in a dose-dependent manner in T2D (Cochran-Armitage trend test: p-value < 0.0001). The 14-SNPs cumulative weighted genetic risk score was also associated with increased regression tendency of systolic blood pressure in T2D (SBP = 122.05 + 0.8 x weighted GRS; p-value = 0.0001).

    Conclusions
    A cumulative weighted genetic risk score composed of 14 SNPs is important for hypertension, increased tendency of systolic blood pressure, and may contribute to hypertension risk in T2D in Taiwan.
    Relation: AMERICAN JOURNAL OF HYPERTENSION hpaa203
    DOI: 10.1093/ajh/hpaa203
    Appears in Collections:[Graduate Institute & Department of Statistics] Journal Article

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