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    题名: Effects of Poor Hepatic Reserve in Cirrhotic Patients with Bacterial Infections: A Population‑based Study
    作者: Hung, Tsung-Hsing;Tsai, Chih-Chun;Leea, Hsing-Feng
    关键词: Bacterial infections;Complications;Liver cirrhosis
    日期: 2019-02-18
    上传时间: 2020-07-02 12:10:36 (UTC+8)
    摘要: Objective: Ascites, hepatic encephalopathy, hepatorenal syndrome, spontaneous bacterial peritonitis, and esophageal variceal bleeding are major complications associated with cirrhosis. The presence of these complications indicates poor hepatic reserve. This study aimed to identify the effects of poor hepatic reserve on mortality in cirrhotic patients with bacterial infections.
    Patients and methods: The Taiwan National Health Insurance Database was used to identify 43,042 cirrhotic patients with bacterial infections hospitalized between January 1, 2010, and December 31, 2013, after propensity score matching analysis. Of these, 21,521 cirrhotic patients had major cirrhotic-related complications and were considered to have poor hepatic reserve.
    Results: Mortality rates at 30 and 90 days were 24.2% and 39.5% in the poor hepatic reserve group and 12.8% and 21.7% in the good hepatic reserve group, respectively (P < 0.001 for each group). The cirrhotic patients with poor hepatic reserve (hazard ratio [HR], 2.10; 95% confidence interval [CI] = 2.03-2.18; P < 0.001) had significantly increased mortality at 90 days. The mortality HRs in patients with one, two, and three or more complications compared to patients without complications were 1.92 (95% CI = 1.85-1.99, P < 0.001), 2.61 (95% CI = 2.47-2.77, P < 0.001), and 3.81 (95% CI = 3.18-4.57, P < 0.001), respectively.
    Conclusion: In cirrhotic patients with bacterial infections, poor hepatic reserve is associated with a poor prognosis. The presence of three or more cirrhotic-related complications increases mortality almost four folds.
    關聯: Tzu Chi Medical Journal 32(1), p.47-52
    DOI: 10.4103/tcmj.tcmj_142_18
    显示于类别:[數學學系暨研究所] 期刊論文

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