淡江大學機構典藏:Item 987654321/118845
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    Title: Effects of Poor Hepatic Reserve in Cirrhotic Patients with Bacterial Infections: A Population‑based Study
    Authors: Hung, Tsung-Hsing;Tsai, Chih-Chun;Leea, Hsing-Feng
    Keywords: Bacterial infections;Complications;Liver cirrhosis
    Date: 2019-02-18
    Issue Date: 2020-07-02 12:10:36 (UTC+8)
    Abstract: Objective: Ascites, hepatic encephalopathy, hepatorenal syndrome, spontaneous bacterial peritonitis, and esophageal variceal bleeding are major complications associated with cirrhosis. The presence of these complications indicates poor hepatic reserve. This study aimed to identify the effects of poor hepatic reserve on mortality in cirrhotic patients with bacterial infections.
    Patients and methods: The Taiwan National Health Insurance Database was used to identify 43,042 cirrhotic patients with bacterial infections hospitalized between January 1, 2010, and December 31, 2013, after propensity score matching analysis. Of these, 21,521 cirrhotic patients had major cirrhotic-related complications and were considered to have poor hepatic reserve.
    Results: Mortality rates at 30 and 90 days were 24.2% and 39.5% in the poor hepatic reserve group and 12.8% and 21.7% in the good hepatic reserve group, respectively (P < 0.001 for each group). The cirrhotic patients with poor hepatic reserve (hazard ratio [HR], 2.10; 95% confidence interval [CI] = 2.03-2.18; P < 0.001) had significantly increased mortality at 90 days. The mortality HRs in patients with one, two, and three or more complications compared to patients without complications were 1.92 (95% CI = 1.85-1.99, P < 0.001), 2.61 (95% CI = 2.47-2.77, P < 0.001), and 3.81 (95% CI = 3.18-4.57, P < 0.001), respectively.
    Conclusion: In cirrhotic patients with bacterial infections, poor hepatic reserve is associated with a poor prognosis. The presence of three or more cirrhotic-related complications increases mortality almost four folds.
    Relation: Tzu Chi Medical Journal 32(1), p.47-52
    DOI: 10.4103/tcmj.tcmj_142_18
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

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