淡江大學機構典藏:Item 987654321/118637
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 62830/95882 (66%)
Visitors : 4129542      Online Users : 521
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/118637


    Title: Effect of Proton Pump Inhibitors on Mortality of Cirrhotic Patients with Pneumonia
    Authors: Hung, Tsung-Hsing;Tseng, Chih -Wei;Tsai, Chih-Chun;Lee, Hsing-Feng
    Date: 2019-04-25
    Issue Date: 2020-06-01 12:10:39 (UTC+8)
    Abstract: Objective
    Pneumonia is life-threatening in patients with liver cirrhosis. Proton pump inhibitors (PPIs)
    may increase the risk of these patients developing pneumonia. However, whether PPIs
    increase mortality in patients with cirrhosis and pneumonia remain unknown.
    Methods
    We used the Taiwan National Health Insurance Database to enroll 1,201 cirrhotic patients
    with pneumonia without active gastrointestinal bleeding who were receiving PPIs and were
    hospitalized between January 1, 2010 and December 31, 2013. A one-to-three propensity
    score match was performed to select a comparison group based on age, gender, and
    comorbid disorders.
    Results
    The overall 30-day and 90-day all-cause mortality rates were 13.7% and 26.9% in the PPI
    group, and 14.3% and 25.1% in the non-PPI group, respectively. After Cox regression
    model adjusting for age, gender, and comorbid disorders, the hazard ratios of the effect of
    PPIs on 30-day and 30 to 90-day mortality were 0.94 (95% Confidence Interval [CI], 0.79–
    1.12, P = 0.468) and 1.26 (95% CI, 1.05–1.52; P = 0.013), respectively.
    Conclusions
    PPIs were not associated with 30-day mortality among cirrhotic patients with pneumonia but
    not active gastrointestinal bleeding. However, prolonged PPI therapy may be associated
    with higher mortality.
    Relation: PLoS One 14(4), e0216041
    DOI: 10.1371/journal.pone.0216041
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

    Files in This Item:

    File Description SizeFormat
    Effect of Proton Pump Inhibitors on Mortality of Cirrhotic Patients with Pneumonia.pdf520KbAdobe PDF1View/Open
    index.html0KbHTML81View/Open

    All items in 機構典藏 are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - Feedback