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    Title: Effect of Proton Pump Inhibitors on Mortality of Cirrhotic Patients with Pneumonia
    Authors: Hung, Tsung-Hsing;Tseng, Chih -Wei;Tsai, Chih-Chun;Lee, Hsing-Feng
    Date: 2019-04-25
    Issue Date: 2020-06-01 12:10:39 (UTC+8)
    Abstract: Objective
    Pneumonia is life-threatening in patients with liver cirrhosis. Proton pump inhibitors (PPIs)
    may increase the risk of these patients developing pneumonia. However, whether PPIs
    increase mortality in patients with cirrhosis and pneumonia remain unknown.
    Methods
    We used the Taiwan National Health Insurance Database to enroll 1,201 cirrhotic patients
    with pneumonia without active gastrointestinal bleeding who were receiving PPIs and were
    hospitalized between January 1, 2010 and December 31, 2013. A one-to-three propensity
    score match was performed to select a comparison group based on age, gender, and
    comorbid disorders.
    Results
    The overall 30-day and 90-day all-cause mortality rates were 13.7% and 26.9% in the PPI
    group, and 14.3% and 25.1% in the non-PPI group, respectively. After Cox regression
    model adjusting for age, gender, and comorbid disorders, the hazard ratios of the effect of
    PPIs on 30-day and 30 to 90-day mortality were 0.94 (95% Confidence Interval [CI], 0.79–
    1.12, P = 0.468) and 1.26 (95% CI, 1.05–1.52; P = 0.013), respectively.
    Conclusions
    PPIs were not associated with 30-day mortality among cirrhotic patients with pneumonia but
    not active gastrointestinal bleeding. However, prolonged PPI therapy may be associated
    with higher mortality.
    Relation: PLoS One 14(4), e0216041
    DOI: 10.1371/journal.pone.0216041
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

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