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    题名: Statin Use in Cirrhotic Patients with Infectious Diseases: A Population-based Study
    作者: Hung, Tsung-Hsing;Tsai, Chih-Chun;Lee, Hsing-Feng
    日期: 2019-04-24
    上传时间: 2020-06-01 12:10:38 (UTC+8)
    摘要: Background
    Recent studies have shown benefits of statins in patients with liver cirrhosis. However, it is
    still unknown if statins have a beneficial effect on the mortality of cirrhotic patients with bacterial infections.
    Methods
    The Taiwan National Health Insurance Database was searched, and 816 cirrhotic patients
    receiving statins with bacterial infections hospitalized between January 1, 2010 and December 31, 2013 were included in the study. A one-to-four propensity score matching was performed to select a comparison group based on age, sex, and comorbid disorders.
    Results
    The overall 30-day mortalities in statin and non-statin group were 5.3% and 9.8%, respectively (P = 0.001). After Cox regression modeling adjusting for age, sex, and comorbid disorders, the hazard ratio (HR) of statin use on 30-day mortality was 0.52 (95% confidence
    interval [CI]: 0.38–0.72, P<0.001). In subgroup analysis, the 30-day mortality effect of statin
    use was more pronounced in patients with pneumonia (HR = 0.34; 95% CI: 0.19–0.59;
    P<0.001) and bacteremia (HR = 0.55; 95% CI: 0.35–0.85; P = 0.008). Atovastatin (HR =
    0.59; 95% CI: 0.37–0.93) and rosuvastatin (HR = 0.59; 95% CI: 0.36–0.98) were associated
    with a decreased 30-day mortality risk compared to patients not taking statins.
    Conclusions
    Statin use decreases the 30-day mortality of cirrhotic patients with bacteremia and
    pneumonia.
    關聯: PLoS One 14(4), e0215839
    DOI: 10.1371/journal.pone.0215839
    显示于类别:[數學學系暨研究所] 期刊論文

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