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    题名: Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy
    作者: Hsieh, Ai-Ru(謝璦如);Huang, Yu-Chuen;Lin, Hui-Ju;Chang, Ya-Wen;Wu, Chia-Ming;Liao, Wen-Ling;Tsai, Fuu-Jen
    关键词: diabetic nephropathy;diabetic retinopathy;pleiotropic effect
    日期: 2020-01-24
    上传时间: 2020-03-05 12:11:16 (UTC+8)
    摘要: Objective Diabetic nephropathy (DN) and diabetic
    retinopathy (DR) comprise major microvascular
    complications of diabetes that occur with a high
    concordance rate in patients and are considered to
    potentially share pathogeneses. In this case-control
    study, we sought to investigate whether DR-related single
    nucleotide polymorphisms (SNPs) exert pleiotropic effects
    on renal function outcomes among patients with diabetes.
    Research design and methods A total of 33 DR-related
    SNPs were identified by replicating published SNPs and
    via a genome-wide association study. Furthermore, we
    assessed the cumulative effects by creating a weighted
    genetic risk score and evaluated the discriminatory and
    prediction ability of these genetic variants using DN cases
    according to estimated glomerular filtration rate (eGFR)
    status along with a cohort with early renal functional
    decline (ERFD).
    Results Multivariate logistic regression models revealed
    that the DR-related SNPs afforded no individual or
    cumulative genetic effect on the nephropathy risk, eGFR
    status or ERFD outcome among patients with type two
    diabetes in Taiwan.
    Conclusion Our findings indicate that larger studies would
    be necessary to clearly ascertain the effects of individual
    genetic variants and further investigation is also required
    to identify other genetic pathways underlying DN.
    關聯: BMJ Open Diabetes Research & Care 8(1)
    DOI: 10.1136/bmjdrc-2019-000727
    显示于类别:[統計學系暨研究所] 期刊論文

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