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    題名: Respiratory sinus arrhythmia biofeedback therapy may increase heart rate variability activity and decrease reactivity in male patients with major depressive disorder: A pilot study
    作者: Lin, Ching-En;Li-Fen Chen, Chia-Chi Chen, Hsin-Yin Chang, Yue-Cune Chang, Jia-Fu Lee
    關鍵詞: biofeedback therapy, depression, respiratory sinus arrhythmia, treatment response
    日期: 2019-09
    上傳時間: 2020-02-12 12:10:29 (UTC+8)
    出版者: Wolters Kluwer - Medknow
    摘要: Objectives: Evidence suggests that depression is associated with a decreased trend of heart rate variability (HRV), which has been considered
    to be associated with unfavorable physical outcomes, and not resolved using various antidepressant medication treatments despite resolution
    of depression symptoms. In the present study, we intended to evaluate the effectiveness of HRV in respiratory sinus arrhythmia-biofeedback
    therapy (RSA-BT) on depression and HRV. Methods: We recruited 67 depressed male patients who received antidepressant or benzodiazepine
    treatments, received a psychological assessment, and were followed with a 3-week, 6-session RSA-BT. Results: After RSA-BT, HRV reactivity
    showed a significant mean decrease of 6.06 in low-frequency normal unit (p = 0.001) and 0.24 in the low-frequency/high-frequency (LF/HF)
    ratio (p < 0.05) and borderline but nonsignificant increase of 2.63 in HF normal unit (HFnu) during the stress task compared with those data
    at baseline (rest), indicating parasympathetic dominance during mental stress. At resting, post-RSA-BT showed a significant increase in LF,
    total power, variation (VAR), LFnu, and LF/HF (p = 0.001) and a significant decrease in HFnu (p = 0.001), indicating HRV activity increase
    and a shift autonomic nervous balance to sympathetic side compared to pre-RSA-BT data. Those patients also showed significant reductions in
    depression severity post-RSA-BT (p < 0.001) after controlling medication effect. Conclusion: The study results highlight the potential rôle of
    RSA-BT on the increased HRV activity with a shift sympathetic predominance at rest and decreased HRV reactivity toward parasympathetic
    dominance during mental stress in patients with depression, which is not related to the effects of antidepressant or benzodiazepine medicatio
    關聯: Taiwanese Journal of Psychiatry 33, p.148‑154
    DOI: 10.4103/TPSY.TPSY_29_19
    顯示於類別:[數學學系暨研究所] 期刊論文

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