The new United States-Mexico-Canada Agreement or USMCA has been conceived as an updated version and replacement to the North American Free Trade Agreement (NAFTA), in place for almost 25 years. Concerned by the urgency to continue attracting foreign direct investment and avoid a further depreciation of its currency, the Mexican government agreed to a series of demands made by the United States and Canada, hence opening the door for a reconfiguration of regional economic integration between the three countries. This paper presents the main considerations behind the new trade agreement and how Mexico plays an important piece in the reconfiguration of regional economic integration in North America, and how the US plans to modify the nature of its trade interactions with the Asia Pacific could have a deep impact on Mexico's trade and investment links with this part of the world.