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    题名: New indications of potential rat intestinal α-glucosidase inhibition by Syzygium zeylanicum (L.) and its hypoglycemic effect in mice
    作者: Nguyen, Van Bon;Wang, San-Lang;Nguyen, Thi Hanh;Doan, Chien Thang;Tran, Thi Ngoc;Kuo, Yao-Haur;Nguyen, Quang Vinh;Nguyen, Anh Dzung
    关键词: α-Glucosidase inhibitors;Diabetes;Syzygium zeylanicum (L.);Hypoglycemic efect
    日期: 2019-10-15
    上传时间: 2019-10-17 12:10:17 (UTC+8)
    出版者: Springers
    摘要: Natural α-glucosidase inhibitors (aGIs) have been considered efective agents for type 2 diabetes management. In this study, Syzygium zeylanicum (L.) (SZL), a medicinal plant that grows wild in the Central Highlands of Vietnam, was reported for the frst time to have potential anti-diabetic properties. The methanol extract of SZL possessed potent rat intestinal α-glucosidase inhibitory activity with low IC50
    and great maximum inhibition values of 109 µg/mL and 100%, respectively. This was higher activity than acarbose, an anti-diabetic drug with IC50 and maximum inhibition values of 540 µg/ml and 80%, respectively. In specifc inhibition tests, the herbal extract demonstrated strong inhibition against α-glucosidases from Saccharomyces cerevisiae and Bacillus stearothermophilus with small IC50 values of
    0.18 and 0.31 µg/mL, respectively. SZL extract also demonstrated potent inhibition against porcine pancreatic α-amylase with maximum inhibition and IC50 values of 99.2% and 3.7 µg/mL, respectively. SZL displayed high thermal and pH stability,
    with respective activities of 87% and 100–140% when treated at 100 °C or over a wide pH range of 2–13. The herbal extract was further investigated for its efcacy
    using ICR mice as the animal model. At a dose of 100 mg/kg BW, SZL signifcantly reduced blood glucose in mice and no signs of diarrhea were observed. The results from this study suggest that SZL, a potent and natural source of aGIs, may be a good candidate for the treatment of type 2 diabetes.
    關聯: Research on Chemical Intermediates
    DOI: 10.1007/s11164-019-04019-4
    显示于类别:[化學學系暨研究所] 期刊論文

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