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https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/117472
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题名: | New indications of potential rat intestinal α-glucosidase inhibition by Syzygium zeylanicum (L.) and its hypoglycemic effect in mice |
作者: | Nguyen, Van Bon;Wang, San-Lang;Nguyen, Thi Hanh;Doan, Chien Thang;Tran, Thi Ngoc;Kuo, Yao-Haur;Nguyen, Quang Vinh;Nguyen, Anh Dzung |
关键词: | α-Glucosidase inhibitors;Diabetes;Syzygium zeylanicum (L.);Hypoglycemic efect |
日期: | 2019-10-15 |
上传时间: | 2019-10-17 12:10:17 (UTC+8) |
出版者: | Springers |
摘要: | Natural α-glucosidase inhibitors (aGIs) have been considered efective agents for type 2 diabetes management. In this study, Syzygium zeylanicum (L.) (SZL), a medicinal plant that grows wild in the Central Highlands of Vietnam, was reported for the frst time to have potential anti-diabetic properties. The methanol extract of SZL possessed potent rat intestinal α-glucosidase inhibitory activity with low IC50 and great maximum inhibition values of 109 µg/mL and 100%, respectively. This was higher activity than acarbose, an anti-diabetic drug with IC50 and maximum inhibition values of 540 µg/ml and 80%, respectively. In specifc inhibition tests, the herbal extract demonstrated strong inhibition against α-glucosidases from Saccharomyces cerevisiae and Bacillus stearothermophilus with small IC50 values of 0.18 and 0.31 µg/mL, respectively. SZL extract also demonstrated potent inhibition against porcine pancreatic α-amylase with maximum inhibition and IC50 values of 99.2% and 3.7 µg/mL, respectively. SZL displayed high thermal and pH stability, with respective activities of 87% and 100–140% when treated at 100 °C or over a wide pH range of 2–13. The herbal extract was further investigated for its efcacy using ICR mice as the animal model. At a dose of 100 mg/kg BW, SZL signifcantly reduced blood glucose in mice and no signs of diarrhea were observed. The results from this study suggest that SZL, a potent and natural source of aGIs, may be a good candidate for the treatment of type 2 diabetes. |
關聯: | Research on Chemical Intermediates |
DOI: | 10.1007/s11164-019-04019-4 |
显示于类别: | [化學學系暨研究所] 期刊論文
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