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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/117106


    Title: Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma
    Authors: Hsieh, Ai-Ru;CM, Chu;CT, Yeh;HG, Lin;SY, Wan;YC, Chen;CL, Hsu;SM, Lin;SJ, Fann Cathy;Tai, Dar-In
    Keywords: Familial generation;Sex;Hepatitis B virus;Perinatal infection;Viral replication
    Date: 2017-02-07
    Issue Date: 2019-09-24 12:11:02 (UTC+8)
    Abstract: AIM
    To explore factors associated with persistent hepatitis B virus (HBV) infection in a cohort of hepatocellular carcinoma (HCC)-affected families and then investigate factors that correlate with individual viral load among hepatitis B surface antigen (HBsAg)-positive relatives.

    METHODS
    We evaluated non-genetic factors associated with HBV replication in relatives of patients with HCC. Relatives of 355 HCC cases were interviewed using a structured questionnaire. Demographics, relationship to index case, HBsAg status of mothers and index cases were evaluated for association with the HBV persistent infection or viral load by generalized estimating equation analysis.

    RESULTS
    Among 729 relatives enrolled, parent generation (P = 0.0076), index generation (P = 0.0044), mothers positive for HBsAg (P = 0.0007), and HBsAg-positive index cases (P = 5.98 × 10-8) were associated with persistent HBV infection. Factors associated with HBV viral load were evaluated among 303 HBsAg-positive relatives. Parent generation (P = 0.0359) and sex (P = 0.0007) were independent factors associated with HBV viral load. The intra-family HBV viral load was evaluated in families clustered with HBsAg-positive siblings. An intra-family trend of similar HBV viral load was found for 27 of 46 (58.7%) families. Male offspring of HBsAg-positive mothers (P = 0.024) and older siblings were associated with high viral load.

    CONCLUSION
    Sex and generation play important roles on HBV viral load. Maternal birth age and nutritional changes could be the reasons of viral load difference between generations.
    Relation: World Journal of Gastroenterology 23(5), p.876-884
    DOI: 10.3748/wjg.v23.i5.876
    Appears in Collections:[Graduate Institute & Department of Statistics] Journal Article

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