淡江大學機構典藏:Item 987654321/117105
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 58237/91808 (63%)
造访人次 : 13785200      在线人数 : 58
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/117105


    题名: On the use of multifactor dimensionality reduction (MDR) and classification and regression tree (CART) to identify haplotype-haplotype interactions in genetic studies
    作者: Hsieh, Ai-Ru;CL, Hsiao;SW, Chang;HM, Wang;SJ, Fann Cathy
    关键词: Gene–gene interaction;Haplotype;MDR;CART
    日期: 2011-02
    上传时间: 2019-09-24 12:11:00 (UTC+8)
    出版者: ELSEVIER
    摘要: Haplotype-based approaches may have greater power than single-locus analyses when the SNPs are in strong linkage disequilibrium with the risk locus. To overcome potential complexities owing to large numbers of haplotypes in genetic studies, we evaluated two data mining approaches, multifactor dimensionality reduction (MDR) and classification and regression tree (CART), with the concept of haplotypes considering their haplotype uncertainty to detect haplotype–haplotype (HH) interactions. In evaluation of performance for detecting HH interactions, MDR had higher power than CART, but MDR gave a slightly higher type I error. Additionally, we performed an HH interaction analysis with a publicly available dataset of Parkinson's disease and confirmed previous findings that the RET proto-oncogene is associated with the disease. In this study, we showed that using HH interaction analysis is possible to assist researchers in gaining more insight into identifying genetic risk factors for complex diseases.
    關聯: Genomics 97(2), p.77-85
    DOI: 10.1016/j.ygeno.2010.11.003
    显示于类别:[統計學系暨研究所] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML36检视/开启
    On the use of multifactor dimensionality reduction (MDR) and classification and regression tree (CART) to identify haplotype–haplotype interactions in genetic studies.pdf679KbAdobe PDF0检视/开启

    在機構典藏中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回馈