淡江大學機構典藏:Item 987654321/117103
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 57525/91039 (63%)
造访人次 : 13507010      在线人数 : 397
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/117103


    题名: Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan
    作者: Lin, Ying-Ju;Liao, Wen-Ling;Wang, Chung-Hsing;Tsai, Li-Ping;Tang, Chih-Hsin;Chen, Chien-Hsiun;Wu, Jer-Yuarn;Liang, Wen-Miin;Hsieh, Ai-Ru;Cheng, Chi-Fung;Chen, Jin-Hua;Chien, Wen-Kuei;Lin, Ting-Hsu;Wu, Chia-Ming;Liao, Chiu-Chu;Huang, Shao-Mei;Tsai, Fuu-Jen
    关键词: Risk factors;Genome-wide association studies
    日期: 2017-07-25
    上传时间: 2019-09-24 12:10:55 (UTC+8)
    摘要: Human height can be described as a classical and inherited trait model. Genome-wide association studies (GWAS) have revealed susceptible loci and provided insights into the polygenic nature of human height. Familial short stature (FSS) represents a suitable trait for investigating short stature genetics because disease associations with short stature have been ruled out in this case. In addition, FSS is caused only by genetically inherited factors. In this study, we explored the correlations of FSS risk with the genetic loci associated with human height in previous GWAS, alone and cumulatively. We systematically evaluated 34 known human height single nucleotide polymorphisms (SNPs) in relation to FSS in the additive model (p < 0.00005). A cumulative effect was observed: the odds ratios gradually increased with increasing genetic risk score quartiles (p < 0.001; Cochran-Armitage trend test). Six affected genes—ZBTB38, ZNF638, LCORL, CABLES1, CDK10, and TSEN15—are located in the nucleus and have been implicated in embryonic, organismal, and tissue development. In conclusion, our study suggests that 13 human height GWAS-identified SNPs are associated with FSS risk both alone and cumulatively.
    關聯: Scientific Reports 7, p.6372
    DOI: 10.1038/s41598-017-06766-z
    显示于类别:[統計學系暨研究所] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan.pdf1181KbAdobe PDF0检视/开启
    index.html0KbHTML37检视/开启

    在機構典藏中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回馈