数据加载中.....
|
jsp.display-item.identifier=請使用永久網址來引用或連結此文件:
https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/117103
|
| 题名: | Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan |
| 作者: | Lin, Ying-Ju;Liao, Wen-Ling;Wang, Chung-Hsing;Tsai, Li-Ping;Tang, Chih-Hsin;Chen, Chien-Hsiun;Wu, Jer-Yuarn;Liang, Wen-Miin;Hsieh, Ai-Ru;Cheng, Chi-Fung;Chen, Jin-Hua;Chien, Wen-Kuei;Lin, Ting-Hsu;Wu, Chia-Ming;Liao, Chiu-Chu;Huang, Shao-Mei;Tsai, Fuu-Jen |
| 关键词: | Risk factors;Genome-wide association studies |
| 日期: | 2017-07-25 |
| 上传时间: | 2019-09-24 12:10:55 (UTC+8) |
| 摘要: | Human height can be described as a classical and inherited trait model. Genome-wide association studies (GWAS) have revealed susceptible loci and provided insights into the polygenic nature of human height. Familial short stature (FSS) represents a suitable trait for investigating short stature genetics because disease associations with short stature have been ruled out in this case. In addition, FSS is caused only by genetically inherited factors. In this study, we explored the correlations of FSS risk with the genetic loci associated with human height in previous GWAS, alone and cumulatively. We systematically evaluated 34 known human height single nucleotide polymorphisms (SNPs) in relation to FSS in the additive model (p < 0.00005). A cumulative effect was observed: the odds ratios gradually increased with increasing genetic risk score quartiles (p < 0.001; Cochran-Armitage trend test). Six affected genes—ZBTB38, ZNF638, LCORL, CABLES1, CDK10, and TSEN15—are located in the nucleus and have been implicated in embryonic, organismal, and tissue development. In conclusion, our study suggests that 13 human height GWAS-identified SNPs are associated with FSS risk both alone and cumulatively. |
| 關聯: | Scientific Reports 7, p.6372 |
| DOI: | 10.1038/s41598-017-06766-z |
| 显示于类别: | [統計學系暨研究所] 期刊論文
|
文件中的档案:
| 档案 |
描述 |
大小 | 格式 | 浏览次数 |
|---|
| Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan.pdf | | 1181Kb | Adobe PDF | 1 | 检视/开启 | | index.html | | 0Kb | HTML | 140 | 检视/开启 |
|
在機構典藏中所有的数据项都受到原著作权保护.
|
