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https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/117011
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| 題名: | A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese |
| 作者: | Chang SW, Fann Cathy SJ, Su WH, Wang YC, Weng CC, Yu CJ, Hsu CL, Hsieh Ai-Ru, Chien RN, Chu CM, Tai DI |
| 日期: | 2014-06-18 |
| 上傳時間: | 2019-09-17 12:11:36 (UTC+8) |
| 摘要: | It is common to observe the clustering of chronic hepatitis B surface antigen (HBsAg) carriers in families. Intra-familial transmission of hepatitis B virus (HBV) could be the reason for the familial clustering of HBsAg carriers. Additionally, genetic and gender factors have been reported to be involved. We conducted a three-stage genome-wide association study to identify genetic factors associated with chronic HBV susceptibility. A total of 1,065 male controls and 1,623 male HBsAg carriers were included. The whole-genome genotyping was done on Illumina HumanHap550 beadchips in 304 healthy controls and HumanHap610 beadchips in 321 cases. We found that rs9277535 (HLA-DPB1, P = 4.87×10−14), rs9276370 (HLA-DQA2, P = 1.9×10−12), rs7756516 and rs7453920 (HLA-DQB2, P = 1.48×10−11 and P = 6.66×10−15 respectively) were significantly associated with persistent HBV infection. A novel SNP rs9366816 near HLA-DPA3 also showed significant association (P = 2.58×10−10). The “T-T-G-G-T” haplotype of the five SNPs further signified their association with the disease (P = 1.48×10−12; OR = 1.49). The “T-T” haplotype composed of rs7756516 and rs9276370 was more prevalent in severe disease subgroups and associated with non-sustained therapeutic response (P = 0.0262). The “G-C” haplotype was associated with sustained therapeutic response (P = 0.0132; OR = 2.49). We confirmed that HLA-DPB1, HLA-DQA2 and HLA-DQB2 loci were associated with persistent HBV infection in male Taiwan Han-Chinese. In addition, the HLA-DQA2 and -DQB2 complex was associated with clinical progression and therapeutic response. |
| 關聯: | PLoS One 9(6), p.e9972 |
| DOI: | 10.1371/journal.pone.0099724 |
| 顯示於類別: | [統計學系暨研究所] 期刊論文
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