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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/116939

    Title: Autism Associated with Anti-NMDAR: Encephalitis Glutamate-Related Therapy
    Authors: Tzang, Ruu-Fen;Chang, Chuan-Hsin;Chang, Yue-Cune;Lane, Hsien-Yuan
    Keywords: autoimmune autism;glutamate-related therapy;anti-N-methyl-D-aspartate receptor encephalitis;immune therapy;dysfunctional glutamate neurotransmission
    Date: 2019-06-21
    Issue Date: 2019-09-10 12:11:13 (UTC+8)
    Abstract: The purpose of this review is to correlate autism with autoimmune dysfunction in the absence
    of an explanation for the etiology of autism spectrum disorder. The anti-N-methyl-Daspartate
    receptor (anti-NMDAR) autoantibody is a typical synaptic protein that can bind to
    synaptic NMDA glutamate receptors, leading to dysfunctional glutamate neurotransmission
    in the brain that manifests as psychiatric symptoms (psychosis, hallucinations, and
    personality changes). Detection of autoantibodies, cytokines, decreased lymphocytes,
    serum immunoglobulin level imbalance, T-cell mediated immune profile, maternal infection
    history, and children’s infection history can all be vital biological markers of autoimmune
    autism. Diagnosing autoimmune encephalitis sooner can increase the effectiveness of
    curative treatments—such as immune therapy or immune modulatory therapy—that may
    prevent the long-term consequence of being misdiagnosed with autism spectrum disorder.
    Glutamate therapy primarily normalizes glutamate neurotransmission and can be a new
    add-on intervention alongside antipsychotics for treating autoimmune autism.
    Relation: Frontiers in Psychiatry 10, p.440
    DOI: 10.3389/fpsyt.2019.00440
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

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