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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/116937


    Title: Gamma knife radiosurgery for the treatment of cavernous sinus meningiomas: post-treatment long-term clinical outcomes, complications, and volume changes
    Authors: Hung, Yi‑Chieh;Lee, Cheng‑Chia;Guo, Wan‑Yuo;Shiau, Cheng‑Ying;Chang, Yue‑Cune;Pan, David Hung‑Chi;Sheehan, Jason P.;Chung, Wen‑Yuh
    Keywords: Cavernous sinus;Meningioma;Prognostic factor;Radiosurgery
    Date: 2019-04-24
    Issue Date: 2019-09-10 12:11:08 (UTC+8)
    Publisher: Springer US
    Abstract: Purpose To evaluate the outcomes of patients who underwent Gamma Knife radiosurgery (GKRS) for the treatment of
    cavernous sinus (CS) meningiomas.
    Methods We retrospectively reviewed the clinical and radiological outcomes of 95 patients with CS meningiomas at Taipei
    Veterans General Hospital between 1993 and 2011. The study cohort comprised 27 men and 68 women with a median age
    of 50 years (range 29–79 years). The median pre-GKRS tumor volume was 6.6 ml (range 0.9–35.7 ml). The median margin
    dose was 12 Gy (range 11–21 Gy). The clinical factors related to favorable outcomes were assessed.
    Results The median follow-up period was 59 (range 12–209) months. At the final follow-up, the tumor volume regressed in
    70 patients (74%) and progressed in eight (8%). Kaplan–Meier analysis revealed that the progression-free survival rates at 5
    and 10 years were 92.7% and 81.2%, respectively. Three patients (3.2%) experienced exacerbated cranial nerve dysfunction
    following radiosurgery. Confined tumors were found to be an independent prognostic factor for tumor control and shorter
    times to regression in the multivariable analyses. No risk factor for tumor progression was identified in either the univariate
    or multivariate analyses.
    Conclusions GKRS provides good long-term tumor control and is associated with low cranial nerve–related morbidity development
    rates in patients with small- to medium-sized CS meningiomas. Confined tumor could be an independent prognostic
    factor for tumor control and shorter times to regression in multivariate analysis. Life-long follow-up is mandatory in such
    settings, even for outpatients with shrunken or stabilized tumors.
    Relation: Journal of Neuro-oncology 141(2), p.261-270
    DOI: 10.1007/s11060-019-03090-6
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

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