English  |  正體中文  |  简体中文  |  Items with full text/Total items : 58210/91779 (63%)
Visitors : 13777133      Online Users : 45
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/116825

    Title: Thermodynamics and Kinetics of Protein Folding and Aggregation
    Authors: Tsai, Min-Yeh;Yuan, Jian-Min;Lin, Sheng Hsien
    Date: 2017-08
    Issue Date: 2019-06-06 12:10:29 (UTC+8)
    Publisher: World Scientific
    Abstract: Thermodynamic and kinetic properties of proteins affect their folding and aggregation processes, which are responsible for a range of biological functions in cells. This chapter aims to introduce simple models of protein folding and aggregation, the nucleation–growth kinetics of protein aggregation, and its study in thermodynamic interpretation of aggregation mechanism. We first review the two-state thermodynamics of protein folding and a generalized two-state scheme, i.e., Ising model. Several Ising-based protein models are discussed, including a generalized Ising model for studying mean-field theory of protein folding and a modified Wako-Saitô-Muñoz-Eaton (M-WSME) model for describing foldon behavior of protein. Also, we review some mechanisms of protein aggregation and a statistical mechanical approach in addressing aggregation equilibrium properties. Finally, we report our recent work on the kinetics of protein aggregation using a kinetic Ising model and discuss diverse aggregation scenarios through a kinetic survey over four different amyloid proteins.
    Relation: Biophysics and Biochemistry of Protein Aggregation: Experimental and Theoretical Studies on Folding, Misfolding, and Self-Assembly of Amyloidogenic Peptides
    DOI: 10.1142/9789813202382_0006
    Appears in Collections:[Graduate Institute & Department of Chemistry] Chapter

    Files in This Item:

    File Description SizeFormat
    Thermodynamics and Kinetics of Protein Folding and Aggregation.pdf1070KbAdobe PDF0View/Open

    All items in 機構典藏 are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - Feedback