Synthesis of pH-sensitive sulfonamide-based hydrogels with controllable crosslinking density by post thermo-curing

doi:10.1007/s10965-018-1672-6

淡江大學機構典藏 > 工學院 > 化學工程與材料工程學系暨研究所 > 期刊論文 > Item 987654321/116002

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题名:	Synthesis of pH-sensitive sulfonamide-based hydrogels with controllable crosslinking density by post thermo-curing
作者:	Don, Trong-ming
关键词:	Sulfonamidemonomer;Hydrogels;pH-sensitive;Swelling ratio;Crosslinking
日期:	2019-01-02
上传时间:	2019-03-16 12:11:12 (UTC+8)
出版者:	Springer
摘要:	Sulfonamide-containing linear copolymers were synthesized via copolymerization of N-(4-methacrylamido)-N′-(4,6-dimethylpyrimidin-2-yl) benzene-1-sulfonamide (SAM) and N,N′-dimethylacrylamide (DMAAm) via free-radical polymerization at room temperature using redox initiators. The redox-initiated polymerization could undergo nearly complete reaction in which the copolymer composition was almost the same as the feeding monomer ratio. These linear copolymers could be dissolved in water and displayed pH-sensitive properties around the physiological pH value of human body with a very sharp transition window less than 0.1 pH unit. Moreover, by introducing N-methyloyl acrylamide (NMA) monomer into the reaction system, the resulting copolymers could become crosslinked hydrogels when subjected to post thermo-curing through the NMA units. The crosslinking density and pH-sensitivity could be manipulated by changing the curing time and temperature. Therefore, swelling ratio and gel fraction of hydrogels could be accurately tailored. The pH-sensitive windows of these hydrogels were found to maintain in between 6.80 to 7.40, which implied that these hydrogels would be a suitable candidate for biomedical materials.
關聯:	Journal of Polymer Research 26(1), Article:18
DOI:	10.1007/s10965-018-1672-6
显示于类别:	[化學工程與材料工程學系暨研究所] 期刊論文

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