Synthesis of Novel Isoquinolino[5,4-ab]phenanthridine Derivatives via Pictet–Spengler Reaction

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/115975

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題名:	Synthesis of Novel Isoquinolino[5,4-ab]phenanthridine Derivatives via Pictet–Spengler Reaction
作者:	Tsai, Min-Chen;Huang, Pei Yu;Syu, Liang Sheng;Shih, Tzenge-Lien
關鍵詞:	homophthalimide;isoquinoline-1,3-dione;naphthalimide;phenanthridine;Pictet;Spengler reaction;Suzuki–Miyaura cross-coupling reaction
日期:	2019-03-03
上傳時間:	2019-03-14 12:10:52 (UTC+8)
摘要:	The reaction of 5-amino-2-[2 (dimethylamino)ethyl]-6-phenyl-1H-benzo[de]isoquinoline-1,3(2H)-dione with a series of aldehydes in acidic media (phosphoric acid, trifluoromethanesulfonic acid, and trifluoroacetic acid) is described. This key step is based on the Pictet–Spengler reaction to synthesize ten novel isoquinolino[5,4-ab]phenanthridine derivatives. The most effective acid is phosphoric acid and optimized yields were obtained. The frameworks of target compounds are unique and have never been reported.
關聯:	Synthesis 51(6), pp.1377-1382
DOI:	10.1055/s-0037-1610670
顯示於類別:	[化學學系暨研究所] 期刊論文

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