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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/115975


    Title: Synthesis of Novel Isoquinolino[5,4-ab]phenanthridine Derivatives via Pictet–Spengler Reaction
    Authors: Tsai, Min-Chen;Huang, Pei Yu;Syu, Liang Sheng;Shih, Tzenge-Lien
    Keywords: homophthalimide;isoquinoline-1,3-dione;naphthalimide;phenanthridine;Pictet;Spengler reaction;Suzuki–Miyaura cross-coupling reaction
    Date: 2019-03-03
    Issue Date: 2019-03-14 12:10:52 (UTC+8)
    Abstract: The reaction of 5-amino-2-[2 (dimethylamino)ethyl]-6-phenyl-1H-benzo[de]isoquinoline-1,3(2H)-dione with a series of aldehydes in acidic media (phosphoric acid, trifluoromethanesulfonic acid, and trifluoroacetic acid) is described. This key step is based on the Pictet–Spengler reaction to synthesize ten novel isoquinolino[5,4-ab]phenanthridine derivatives. The most effective acid is phosphoric acid and optimized yields were obtained. The frameworks of target compounds are unique and have never been reported.
    Relation: Synthesis 51(6), pp.1377-1382
    DOI: 10.1055/s-0037-1610670
    Appears in Collections:[Graduate Institute & Department of Chemistry] Journal Article

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