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    题名: Production of potent antidiabetic compounds from shrimp head powder via Paenibacillus conversion
    作者: Van Bon Nguyen;San-Lang Wang
    关键词: Shrimp heads;Marine processing;Antidiabetes;Paenibacillus;Nicotinic acid, Adenine
    日期: 2019
    上传时间: 2019-01-02 12:10:17 (UTC+8)
    出版者: Elsevier
    摘要: Natural α-glucosidase inhibitors (aGIs) are of great interest as an efficacious and safe therapy for type 2 diabetes, which is an ongoing global health issue. The aim of this study is to utilize shrimp head powder (SHP), an abundant and low-cost material, for the biosynthesis, isolation, and identification of active antidiabetic compounds. SHP was efficiently converted to aGIs via Paenibacillus sp. TKU042 fermentation. Fermented SHP (fSHP)
    by this strain possesses high pH stability, and stronger yeast α-glucosidase inhibitory activity (92%) than that of acarbose (60%). aGI productivity increased more than 2-fold after optimization (from 225 U/mL to 560 U/mL). Further bioactivity-guided isolation of two major active compounds were identified as nicotinic acid and adenine. Notably, these inhibitors were non-sugar-based moiety aGIs, which is newly isolated and identified from fSHP in this study. In the tests of specific enzyme inhibitory activity, adenine showed highly specific inhibition against yeast α-glucosidase (IC50 = 22 μg/mL); nicotinic acid demonstrated good effect on rat α-glucosidase (IC50 = 70 μg/mL); while acarbose possessed efficient effect on bacteria, rice, and rat α-glucosidases (IC50 = 0.03–108 μg/mL). The current results suggest that it is cost-effective to produce potent aGIs from SHP via Paenibacillus conversion, and these active constituents may be useful in type 2 diabetes management.
    關聯: Process Biochemistry 76, p.18-24
    DOI: 10.1016/j.procbio.2018.11.004
    显示于类别:[化學學系暨研究所] 期刊論文

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