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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/115715

    Title: Bioactivity-guided purification of novel herbal antioxidant and anti-NO compounds from Euonymus laxiflorus Champ
    Authors: Van Bon Nguyen;San-Lang Wang;Anh Dzung Nguyen;Zhi-Hu Lin;Chien Thang Doan;Thi Ngoc Tran;Hung Tse Huang;Yao-Haur Kuo
    Keywords: antioxidants;anti-NO;Euonymus laxiflorus;Walterolactone A (1a) and B (1b) β-D-glucopyranoside;bioactive compounds
    Date: 2019
    Issue Date: 2019-01-02 12:10:13 (UTC+8)
    Publisher: MDPI
    Abstract: Euonymus laxiflorus Champ., a medicinal herb collected in Vietnam, has been reported
    to show several potent bioactivities, including anti-NO, enzyme inhibition, hypoglycemic and
    antidiabetic effects. Recently, the antioxidant activity of Euonymus laxiflorus Champ. trunk bark
    (ELCTB) has also been reported. However, the active antioxidant and anti-NO constituents existing
    in ELCTB have not been reported in the literature. The objective of this study was to purify the active
    antioxidants from ELCTB and investigate the anti-NO effect of the major constituents. Twenty-two
    phenolics isolated from ELCTB, including 12 compounds newly isolated in this study (1–12) and
    10 constituents obtained from our previous work, were evaluated for their antioxidant activity.
    Of these, 12 compounds (4–6, 9, 13–15, 18–22) showed a potent antioxidant capacity (FRS50 =
    7.8–58.11 µg/mL), in comparison to α-tocopherol (FRS50 = 23 µg/mL). In the anti-NO activity tests,
    Walterolactone A (1a) and B (1b) β-D-glucopyranoside (13) demonstrated the most effective and
    comparable activity to that of quercetin with max inhibition and IC50 values of 100%, 1.3 µg/mL, and
    100%, 1.21 µg/mL, respectively. The crude extract and its major compounds showed no cytotoxicity
    on normal cells. Notably, three constituents (9, 11, and 12) were identified as new compounds,
    another three constituents, including 1, 7, and 8, were found to be new natural products, constituents
    9 and 13 were determined to be new antioxidants, and compound 13 was reported to have novel
    potent anti-NO activity for the first time. The results of this study contribute to the enrichment of
    new natural products and compounds, as well as the novel biological activity of constituents isolated
    from Euonymus laxiflorus Champ. The current study also indicates ELCTB as a rich natural source of
    active phenolics. It is suggested that ELCTB could be developed as a health food with promising
    antioxidant and anti-NO effects, as well as other beneficial biological activities.
    Relation: Molecules 24(1), 120
    DOI: 10.3390/molecules24010120
    Appears in Collections:[Graduate Institute & Department of Chemistry] Journal Article

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