本研究採用六標準差設計ICOV手法結合化工程序模擬，強化壬基酚製程，鑑定階段(Identify)定義品質特性，在明確界定設計之規格後，進入特性化分析階段(Characterize)，建立程序流程圖瞭解製程輸入與輸出變數，並以化工程序模擬軟體Aspen Plus建立個案製程模式，藉由二水準全因子實驗，進料比例以及反應器溫度均為關鍵輸入變數，最佳化階段(Optimize)透過反應曲面法分析多個反應曲面後得到製程的最佳參數配製，在驗證階段(Verify)對反應曲面法所獲得的迴歸方程式驗證，並與尚未最佳化的數據進行比較，本研究結果發現最佳參數下，壬基酚產量可提升14%。 In research, Design for Six Sigma ICOV (Identify-Characterize-Optimize-Verify) approach and chemical process simulation are used to optimize Nonylphenol process. In Identify phase, we define the quality characteristics of products. In Measure phase, chemical process simulation software Aspen Plus is simulated to establish process model. In Characterize phase, design of experiments could be used to find out that the key factors affecting the process is phenol-nonene feed ratio and temperature of the reactor. In Optimize phase, response surface methodology is used to find out a set of optimal parameters. In Verify phase, by comparing with the original process, the yield can be increased by 14%.
