銅催化連續合環反應合成類白葉藤鹼及其衍生物

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Title:	銅催化連續合環反應合成類白葉藤鹼及其衍生物
Other Titles:	Copper-catalyzed domino cyclization to synthesize neocryptolepine and its analogues
Authors:	王鴻凱;Wang, Hung-Kai
Contributors:	淡江大學化學學系碩士班謝仁傑;Hsieh, Jen-Chieh
Keywords:	Apocynaceae alkaloid;copper-catalyzed;domino cyclization;neocryptolepine;夾竹桃科生物鹼;連續合環反應;銅催化;類白葉藤鹼
Date:	2017
Issue Date:	2018-08-03 14:46:20 (UTC+8)
Abstract:	第一部分: 利用縮合反應以及氧化還原反應合成所需要的前驅物,接著以烏爾曼型態的反應方式合成出 6H-吲哚[2,3-b]喹及不同取代基的衍生物,並探討其反應的耐受性。第二部分: 將第一部分的產物- 6H-吲哚[2,3-b]喹進一步往後進行合成,合成類白葉藤鹼,總共四步驟全合成反應得到天然生物鹼,其在醫藥方面上具相當的應用性。 The 1st Part : We used condensation reaction and reduction-oxidation reaction to synthesize the starting materials. Then we used Ullmann-type reaction to synthesize 6H-indolo[2,3-b] quinoline and its derivatives. We also changed the different functional groups to test the tolerance of the synthetic strategy. The 2nd Part : By using the final products we get form first part, we successfully develop a new total synthesis to get Apocynaceae alkaloid, Neocryptolepine, in four steps. It has a wide spectrum of application in pharmacology.
Appears in Collections:	[Graduate Institute & Department of Chemistry] Thesis

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