第一部分: 利用縮合反應以及氧化還原反應合成所需要的前驅物,接著以烏爾曼型態的反應方式合成出 6H-吲哚[2,3-b]喹及不同取代基的衍生物,並探討其反應的耐受性。 第二部分: 將第一部分的產物- 6H-吲哚[2,3-b]喹進一步往後進行合成,合成類白葉藤鹼,總共四步驟全合成反應得到天然生物鹼,其在醫藥方面上具相當的應用性。 The 1st Part : We used condensation reaction and reduction-oxidation reaction to synthesize the starting materials. Then we used Ullmann-type reaction to synthesize 6H-indolo[2,3-b] quinoline and its derivatives. We also changed the different functional groups to test the tolerance of the synthetic strategy.
The 2nd Part : By using the final products we get form first part, we successfully develop a new total synthesis to get Apocynaceae alkaloid, Neocryptolepine, in four steps. It has a wide spectrum of application in pharmacology.
