淡江大學機構典藏:Item 987654321/113737
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 62805/95882 (66%)
造訪人次 : 3993080      線上人數 : 295
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋


    請使用永久網址來引用或連結此文件: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/113737


    題名: New records of potent in-vitro antidiabetic properties of Dalbergia tonkinensis heartwood and the bioactivity-guided isolation of active compounds
    作者: Van Bon Nguyen;San-Lang Wang;Ngu Truong Nhan;Thi Hanh Nguyen;Nguyen Phuong Dai Nguyen;Do Huu Nghi;Nguyen Manh Cuong
    關鍵詞: diabetes;Dalbergia tonkinensis;sativanone;formononetin;heartwood;inhibitors
    日期: 2018-06-29
    上傳時間: 2018-07-03 12:10:14 (UTC+8)
    出版者: MDPI
    摘要: Alpha-glucosidase inhibitory activity has been commonly used for the evaluation of antidiabetic
    property in vitro. The aim of this study is to investigate and characterize Dalbergia tonkinensis as a
    potential source of antidiabetic compounds. The screening of the active parts used, such as trunk bark,
    heartwood, and the leaves of Dalbergia tonkinensis indicated that all these extracted parts used with
    methanol demonstrated potent α-glucosidase inhibitory activity. The in vitro antidiabetic property of
    Dalbergia tonkinensis was notably recorded for the first time and showed activity (EC50 = 0.17–0.78 mg/mL)
    comparable to those of reported potent herbal extracts (EC50 = 0.25–4.0 mg/mL) and higher activity
    than that of acarbose, a commercial antidiabetic drug (EC50 = 1.21 mg/mL). The stability tests revealed
    that the heartwood of Dalbergia tonkinensis extract (HDT) possesses high pH stability with relative
    activity in the range of 80–98%. Further bioassay-guided purification led to the isolation of 2 active
    compounds identified as sativanone and formononetin from the ethyl acetate fraction and water
    fraction of HDT, respectively. These α-glucosidase inhibitors (aGIs) show promising inhibition against
    various types of α-glucosidases. Remarkably, these inhibitors were determined as new mammalian
    aGIs, showing good effect on rat α-glucosidase. The results suggest that Dalbergia tonkinensis is a
    potent source of aGIs and suggest promise in being developed as functional food with antidiabetic
    efficacy. The results of this study also enrich our knowledge concerning current biological activity
    and constituents of Dalbergia tonkinensis species.
    關聯: Molecules 23(7), 1589
    DOI: 10.3390/molecules23071589
    顯示於類別:[化學學系暨研究所] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML166檢視/開啟
    New records of potent in-vitro antidiabetic property of Dalbergia tonkinensis heartwood and the bioactivity-guided isolation of active compounds.pdf829KbAdobe PDF168檢視/開啟

    在機構典藏中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋