淡江大學機構典藏:Item 987654321/113737
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    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/113737


    Title: New records of potent in-vitro antidiabetic properties of Dalbergia tonkinensis heartwood and the bioactivity-guided isolation of active compounds
    Authors: Van Bon Nguyen;San-Lang Wang;Ngu Truong Nhan;Thi Hanh Nguyen;Nguyen Phuong Dai Nguyen;Do Huu Nghi;Nguyen Manh Cuong
    Keywords: diabetes;Dalbergia tonkinensis;sativanone;formononetin;heartwood;inhibitors
    Date: 2018-06-29
    Issue Date: 2018-07-03 12:10:14 (UTC+8)
    Publisher: MDPI
    Abstract: Alpha-glucosidase inhibitory activity has been commonly used for the evaluation of antidiabetic
    property in vitro. The aim of this study is to investigate and characterize Dalbergia tonkinensis as a
    potential source of antidiabetic compounds. The screening of the active parts used, such as trunk bark,
    heartwood, and the leaves of Dalbergia tonkinensis indicated that all these extracted parts used with
    methanol demonstrated potent α-glucosidase inhibitory activity. The in vitro antidiabetic property of
    Dalbergia tonkinensis was notably recorded for the first time and showed activity (EC50 = 0.17–0.78 mg/mL)
    comparable to those of reported potent herbal extracts (EC50 = 0.25–4.0 mg/mL) and higher activity
    than that of acarbose, a commercial antidiabetic drug (EC50 = 1.21 mg/mL). The stability tests revealed
    that the heartwood of Dalbergia tonkinensis extract (HDT) possesses high pH stability with relative
    activity in the range of 80–98%. Further bioassay-guided purification led to the isolation of 2 active
    compounds identified as sativanone and formononetin from the ethyl acetate fraction and water
    fraction of HDT, respectively. These α-glucosidase inhibitors (aGIs) show promising inhibition against
    various types of α-glucosidases. Remarkably, these inhibitors were determined as new mammalian
    aGIs, showing good effect on rat α-glucosidase. The results suggest that Dalbergia tonkinensis is a
    potent source of aGIs and suggest promise in being developed as functional food with antidiabetic
    efficacy. The results of this study also enrich our knowledge concerning current biological activity
    and constituents of Dalbergia tonkinensis species.
    Relation: Molecules 23(7), 1589
    DOI: 10.3390/molecules23071589
    Appears in Collections:[Graduate Institute & Department of Chemistry] Journal Article

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