English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 55222/89520 (62%)
造訪人次 : 10721861      線上人數 : 30
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/113399


    題名: Production and bioactivity-guided isolation of antioxidants with α-glucosidase inhibitory and anti-NO properties from marine chitinous materials
    作者: Van Bon Nguyen;Thi Hanh Nguyen;Chien Thang Doan;Thi Ngoc Tran;Anh Dzung Nguyen;Yao-Haur Kuo;San-Lang Wang
    關鍵詞: antioxidants;anti-inflammation;chitin;exopolysaccharides;homogentisic acid
    日期: 2018-05-09
    上傳時間: 2018-05-11 12:10:15 (UTC+8)
    出版者: MDPI
    摘要: Natural and bioactive products have been of great interest due to their benefit as
    health foods and drugs to prevent various diseases. The aim of this study is to efficiently reuse
    marine chitinous materials (CMs), abundant and low-cost fishery by-products, for the bio-synthesis,
    isolation, and identification of antioxidant compounds possessing some other beneficial bioactivities.
    Paenibacillus sp. was used to convert CMs to antioxidants. Among various tested CMs, squid pen
    powder (SPP) gave the best results when used as the sole carbon/nitrogen source. Fermented
    SPP (FSPP) had comparable antioxidant activity (IC50 = 124 µg/mL) to that of α-tocopherol
    (IC50 = 30 µg/mL). The antioxidant productivity increased 1.83-fold after culture optimization.
    The use of multiple techniques, including Diaion, silica, and preparative HPLC columns coupled with
    a bioassay resulted in the isolation of two major antioxidants characterized as exopolysaccharides
    and homogentisic acid. These isolated compounds showed great maximum activity and low
    IC50 values (96%, 30 µg/mL and 99%, 5.4 µg/mL, respectively) which were comparable to that
    of α-tocopherol (95%, 24 µg/mL). The crude sample, fractions, and isolated compounds also
    demonstrated α-glucosidase inhibition and anti–inflammatory activity. Notably, homogentisic
    acid was found as a non-sugar-based moiety α-glucosidase inhibitor which show much higher
    inhibition (IC50 = 215 µg/mL) than that of acarbose (IC50 = 1324 µg/mL) and also possessed
    acceptable anti–inflammatory activity (IC50 = 9.8 µg/mL). The results highlighted the value of
    using seafood processing by-products, like squid pens, for the production of several compounds
    possessing multi-benefit bioactivities and no cytotoxicity.
    關聯: Molecules 23(5), 1124(14 pages)
    DOI: 10.3390/molecules23051124
    顯示於類別:[化學學系暨研究所] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML119檢視/開啟
    Production and bioactivity-guided isolation of antioxidants with α-glucosidase inhibitory and anti-NO properties from marine chitinous materials.pdf1380KbAdobe PDF0檢視/開啟

    在機構典藏中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回饋