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    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/112897

    Title: The Impact of Pharmacological Treatments on Cognitive Function and Severity of Behavioral Symptoms in Geriatric Elder Patients with Dementia
    Authors: Nian-Sheng Tzeng;Wei-Shan Chiang;Shun-Yi Chen;Yu-Ching Chou;Kun-Ming Lee;San-Yuan Huang;Chin-Bin Yeh;Chun-Yen Chen;Hsin-An Chang;Yu-Chen Kao
    Keywords: cognitive function;mini-mental status examination;behavioral and psychological symptoms;neuropsychiatric inventory
    Date: 2017-03
    Issue Date: 2018-03-09 12:10:28 (UTC+8)
    Abstract: This study was to determine the impact of different pharmacological
    treatments on cognitive functions and the severity of the behavioral and psychological
    symptoms (BPSD) in elderly patients with dementia. Methods: The
    study was a prospective, and observational study. We examined 70 older patiens
    with dementia with the Mini-Mental Status examination (MMSE) and the Neuropsychiatric
    Inventory (NPI) Scale at each time of the outpatient visits at the 1st,
    4th, and 12th week, to fi nd out the impacts of antipsychotic drugs, mood stabilizers/antidepressants,
    hypno-sedative, and cognitive enhancers/anti-dementia drugs.
    Results: The majority of dementia types were Alzheimer’s dementia (AD, n = 40,
    57.1%) and vascular dementia (VaD, n = 28, 40%). The caregivers were their
    spouses (n = 10, 14.3%), or children (n = 53, 75.7%). We found that psychotropic
    medications, 27 (38.6%) of the patients used antipsychotic drugs, 25 (35.7%)
    mood stabilizers/antidepressants, 27 (38.6%) hypno-sedatives, and 48 (68.6%)
    cognitive enhancers/anti-dementia drugs. Those medications did not show any signifi
    cant improvements of the MMSE at 12th weeks. Mood stabilizers/antidepressants
    reached a signifi cant decrease in both the NPI severity and the caregiver
    distress scores. Conclusion: In this study, we found that patients with BPSD, receiving
    antipsychotics, mood stabilizers/antidepressants, hypno-sedative and cognitive
    enhancers/anti-dementia drugs did not improve the MMSE scores at the end
    of study, but that those receiving mood stabilizer/antidepressants showed a signifi -
    cant decrease on the behavioral disturbances measured by the NPI scale.
    Relation: Taiwanese Journal of Psychiatry (31)1,p.69-79
    DOI: 10.29478/TJP
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

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