Guava, belonging to family Myrtaceae, is widely grown in tropical
countries. Different parts of guava are reported to have long been used in folk
medicine. In this study, the in vitro and in vivo anti-hyperglycemic activities of
Psidium littorale Raddi leaves extract were investigated. The results indicated that
the leaf extract demonstrates relatively high intestinal a-glucosidase inhibitory
activity in rats, twice as high as acarbose. In addition, the extract also induced
lowering fasting blood glucose levels in streptozotocin- induced diabetic rats at the
dose of 150 mg/kg body weight, and without any effect on normal rats. Moreover,
the extract did not significantly induce body weight loss in rats. The results suggest
that P. littorale Raddi may prove to be useful in treating diabetes in humans.
Relation:
Research on Chemical Intermediates 44(3), p.1745-1753
