Reclamation of shrimp heads for the production of α-glucosidase inhibitors by Staphylococcus sp. TKU043

淡江大學機構典藏 > 理學院 > 化學學系暨研究所 > 期刊論文 > Item 987654321/112851

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题名:	Reclamation of shrimp heads for the production of α-glucosidase inhibitors by Staphylococcus sp. TKU043
作者:	San-Lang Wang;Yu-Cheng Su;Van Bon Nguyen;Anh Dzung Nguyen
关键词:	Chitin;Shrimp head;α-glucosidase inhibitor;Staphylococcus
日期:	2018-02
上传时间:	2018-03-02 12:14:53 (UTC+8)
出版者:	Springer
摘要:	Alpha-glucosidase inhibitors (aGIs) have received much attention due to their important use in treating diabetes mellitus. Although some synthetic aGIs have been available for a long time, they often cause various unexpected side effects. The purpose of this study was to reclaim shrimp heads for the production of aGIs via bacteria. Staphylococcus sp. TKU043, a bacterium strain isolated from Taiwanese soil produced aGIs in a shrimp-head-containing medium. Maximum productivity of aGIs (1457 U/mL) was found after cultivation in 1% shrimp head powder medium for 3 days. The aGI partially purified by column chromatography showed thermal instability, and presumably was a proteinous material. The inhibitor mode of this aGI was determined to be a mixed inhibition mode (non-competitive–uncompetitive inhibition).
關聯:	Research on Chemical Intermediates 44(8), p.4929–4937
DOI:	10.1007/s11164-018-3345-9
显示于类别:	[化學學系暨研究所] 期刊論文

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