Alpha-glucosidase inhibitors (aGIs) have received much attention due to
their important use in treating diabetes mellitus. Although some synthetic aGIs have
been available for a long time, they often cause various unexpected side effects. The
purpose of this study was to reclaim shrimp heads for the production of aGIs via
bacteria. Staphylococcus sp. TKU043, a bacterium strain isolated from Taiwanese
soil produced aGIs in a shrimp-head-containing medium. Maximum productivity of
aGIs (1457 U/mL) was found after cultivation in 1% shrimp head powder medium
for 3 days. The aGI partially purified by column chromatography showed thermal
instability, and presumably was a proteinous material. The inhibitor mode of this
aGI was determined to be a mixed inhibition mode (non-competitive–uncompetitive
inhibition).
Relation:
Research on Chemical Intermediates 44(8), p.4929–4937
