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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/112851


    Title: Reclamation of shrimp heads for the production of α-glucosidase inhibitors by Staphylococcus sp. TKU043
    Authors: San-Lang Wang;Yu-Cheng Su;Van Bon Nguyen;Anh Dzung Nguyen
    Keywords: Chitin;Shrimp head;α-glucosidase inhibitor;Staphylococcus
    Date: 2018-02
    Issue Date: 2018-03-02 12:14:53 (UTC+8)
    Publisher: Springer
    Abstract: Alpha-glucosidase inhibitors (aGIs) have received much attention due to
    their important use in treating diabetes mellitus. Although some synthetic aGIs have
    been available for a long time, they often cause various unexpected side effects. The
    purpose of this study was to reclaim shrimp heads for the production of aGIs via
    bacteria. Staphylococcus sp. TKU043, a bacterium strain isolated from Taiwanese
    soil produced aGIs in a shrimp-head-containing medium. Maximum productivity of
    aGIs (1457 U/mL) was found after cultivation in 1% shrimp head powder medium
    for 3 days. The aGI partially purified by column chromatography showed thermal
    instability, and presumably was a proteinous material. The inhibitor mode of this
    aGI was determined to be a mixed inhibition mode (non-competitive–uncompetitive
    inhibition).
    Relation: Research on Chemical Intermediates 44(8), p.4929–4937
    DOI: 10.1007/s11164-018-3345-9
    Appears in Collections:[Graduate Institute & Department of Chemistry] Journal Article

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