淡江大學機構典藏:Item 987654321/112721
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    Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/112721


    Title: Cartilage MRI T2* relaxation time and perfusion changes of the knee in a 5/6 nephrectomy rat model of chronic kidney disease
    Authors: Wang, Chao-Ying;Peng, Yi-Jen;Hsu, Yu-Juei;Lee, Herng-Sheng;Chang, Yue-Cune;Chang, C.-S.;Chiang, Shih-Wei;Hsu, Yi-Chih;Lin, Ming-Huang;Huang, Guo-Shu
    Keywords: Chronic kidney disease;Dynamic contrast enhanced MRI;MRI T2∗ relaxation time;5/6 Nephrectomy;Cartilage;Knee
    Date: 2017-06-21
    Issue Date: 2018-03-02 12:10:52 (UTC+8)
    Abstract: Objective
    Chronic kidney disease (CKD) is characterized by metabolic disturbances in calcium and phosphorus homeostasis as kidney function declines. Alterations in blood perfusion in bone resulting from arteriosclerosis of bone vessels may relate to the progression of CKD. Herein, change in dynamic contrast enhanced (DCE) MRI parameters (A: amplitude, kel: elimination constant, and kep: permeability rate constant) and MRI T2∗ relaxation time of the knee cartilage were measured in a rodent nephrectomy model in order to (1) examine the relationship of peripheral blood perfusion to CKD and (2) demonstrate the feasibility of using DCE-MRI parameters and MRI T2∗ as imaging biomarkers to monitor disease progression.

    Design
    Two groups of male Sprague–Dawley rats received either (1) no intervention or (2) 5/6 nephrectomy.

    Results
    We found that the CKD group (compared with the control group) had lower A and kel values and similar kep value in the lateral and medial articular cartilages beginning at 12 weeks (P < 0.05); statistically significantly higher T2∗ values in the lateral and medial articular cartilages beginning at 18 weeks (P < 0.05); statistically significantly decreased inner luminal diameter of the popliteal artery, and altered structure of the lateral and medial articular cartilages (P < 0.05).

    Conclusion
    Perfusion deficiency and CKD may be related. DCE parameters and MRI T2∗ could serve as imaging biomarkers of cartilage degeneration in CKD progression.
    Relation: Osteoarthritis and Cartilage 25(6), p.976-985
    DOI: 10.1016/j.joca.2016.12.019
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

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