English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 57615/91160 (63%)
造访人次 : 13557039      在线人数 : 291
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/112721


    题名: Cartilage MRI T2* relaxation time and perfusion changes of the knee in a 5/6 nephrectomy rat model of chronic kidney disease
    作者: Wang, Chao-Ying;Peng, Yi-Jen;Hsu, Yu-Juei;Lee, Herng-Sheng;Chang, Yue-Cune;Chang, C.-S.;Chiang, Shih-Wei;Hsu, Yi-Chih;Lin, Ming-Huang;Huang, Guo-Shu
    关键词: Chronic kidney disease;Dynamic contrast enhanced MRI;MRI T2∗ relaxation time;5/6 Nephrectomy;Cartilage;Knee
    日期: 2017-06-21
    上传时间: 2018-03-02 12:10:52 (UTC+8)
    摘要: Objective
    Chronic kidney disease (CKD) is characterized by metabolic disturbances in calcium and phosphorus homeostasis as kidney function declines. Alterations in blood perfusion in bone resulting from arteriosclerosis of bone vessels may relate to the progression of CKD. Herein, change in dynamic contrast enhanced (DCE) MRI parameters (A: amplitude, kel: elimination constant, and kep: permeability rate constant) and MRI T2∗ relaxation time of the knee cartilage were measured in a rodent nephrectomy model in order to (1) examine the relationship of peripheral blood perfusion to CKD and (2) demonstrate the feasibility of using DCE-MRI parameters and MRI T2∗ as imaging biomarkers to monitor disease progression.

    Design
    Two groups of male Sprague–Dawley rats received either (1) no intervention or (2) 5/6 nephrectomy.

    Results
    We found that the CKD group (compared with the control group) had lower A and kel values and similar kep value in the lateral and medial articular cartilages beginning at 12 weeks (P < 0.05); statistically significantly higher T2∗ values in the lateral and medial articular cartilages beginning at 18 weeks (P < 0.05); statistically significantly decreased inner luminal diameter of the popliteal artery, and altered structure of the lateral and medial articular cartilages (P < 0.05).

    Conclusion
    Perfusion deficiency and CKD may be related. DCE parameters and MRI T2∗ could serve as imaging biomarkers of cartilage degeneration in CKD progression.
    關聯: Osteoarthritis and Cartilage 25(6), p.976-985
    DOI: 10.1016/j.joca.2016.12.019
    显示于类别:[數學學系暨研究所] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    Cartilage MRI T2 relaxation time and perfusion changes of the knee in a 5 6 nephrectomy rat model of chronic kidney disease.pdf2239KbAdobe PDF1检视/开启
    index.html0KbHTML96检视/开启

    在機構典藏中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - 回馈