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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/112696

    Title: New novel α–glucosidase inhibitors produced by microbial conversion
    Authors: Nguyen Van Bon, Wang San-Lang
    Keywords: α–glucosidase inhibitor;Paenibacillus sp.;Diabetes;Microbial conversion
    Date: 2017-11-21
    Issue Date: 2018-02-07 02:10:16 (UTC+8)
    Publisher: Elsevier
    Abstract: Fermented Nutrient Broth (FNB) was found to be a potential source of antidiabetic drugs in the previous report. Thus, FNB was employed to isolate the active compounds in this study. Novel 5 α-glucosidase inhibitors (aGIs) were isolated from FNB and identified as: (1) Adenine, (2) 3-hydroxyproline, (3) Creatinine, (4) Nicotinic acid, and (5) Niacinamide. Notably, these inhibitors were found as new microbial aGIs, non-sugar-based moiety aGIs. Of these inhibitors, compounds 2 and 4 showed activity against rat α-glucosidase equal to, or stronger than, that
    of acarbose, with the IC50 values of 100, 67, and 115 μg/mL, respectively. These results contributed to enriching the current poor novel microbial aGIs, and also confirmed that FNB shows promising utilization for diabetes and obesity treatments or health foods due to their containing efficient mammalian aGIs.
    Relation: Process Biochemistry, v.65, p.228-232
    DOI: 10.1016/j.procbio.2017.11.016
    Appears in Collections:[Graduate Institute & Department of Chemistry] Journal Article

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