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    題名: Isolation and identification of novel α-amylase inhibitors from Euonymus laxiflorus Champ
    作者: Nguyen VB;Wang SL;Nguyen AD;Vo TPK;Zhang LJ;Nguyen QV;Kuo YH
    關鍵詞: α-amylase inhibitor;Euonymus laxiflorus Champ.;Medicinal plants;Diabetes;Obesity;Bioactive compounds
    日期: 2018
    上傳時間: 2018-01-24 02:10:19 (UTC+8)
    出版者: Springer
    摘要: Euonymus laxiflorus Champ. (ELC) has been reported to possess potential
    antidiabetic activity. The aim of this study is to isolate and identify the active
    compounds in ELC extract. Application of effective techniques including Diaoin,
    octadecylsilane opened columns, dialysis, and preparative high-performance liquid
    chromatography (HPLC) coupled with a biologically guided assay resulted in isolation
    of 11 novel active compounds. Five compounds were identified as new α-amylase inhibitors (αAIs), viz. walterolactone A/B β-D-pyranoglucoside (1),
    schweinfurthinol 9-O-β-D-pyranoglucoside (10), 1-O-(3-methyl)-butenoyl-myoinositol (11), leonuriside (13), and (3,5-dimethoxy-4-hydroxyphenol) -1-O-β-D-(6′-O-galloyl)-glucopyranoside (21). Among these inhibitors, three compounds (1, 10, 11) were characterized as new. Another six known compounds (2, 9, 16, 17, 18, 19) were determined as phenolic. Notably, six compounds (1, 2, 9, 13, 16, 17) demonstrated significant activity, comparable to or higher than that of acarbose, a commercial antidiabetic drug, based on t test ranking. The relationship between the chemical structures and bioactivity of the inhibitors is also reported.
    關聯: Research on Chemical Intermediates 44(2), p.1411-1424
    顯示於類別:[化學學系暨研究所] 期刊論文

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