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    题名: Dose-duration reciprocity for G protein activation: modulation of kinase to substrate ratio alters cell signaling
    作者: Liao, Kang-Ling;Melvin, Charles E.;Sozzani, Rosangela;Jones, Roger D.;Elston, Timothy C.;Jones, Alan M.
    关键词: Arabidopsis;Regulator of G Signaling;WNK kinase;heterotrimeric G protein;15 endocytosis;glucose sensor;salt response
    日期: 2017-12-15
    上传时间: 2018-01-03 02:10:42 (UTC+8)
    摘要: In animal cells, activation of heterotrimeric G protein signaling generally occurs when the system’s cognate signal exceeds a threshold, whereas in plant cells, both the amount and the exposure time of at least one signal, D-glucose, are used toward activation. This unusual signaling property called Dose-Duration Reciprocity, first elucidated in the genetic model Arabidopsis thaliana, is achieved by a complex that is comprised of a 7-transmembrane REGULATOR OF G SIGNALING (RGS) protein (AtRGS1), a Gα subunit that binds and hydrolyzes nucleotide, a Gβγ dimer, and three WITH NO LYSINE (WNK) kinases. D-glucose is one of several signals such as salt and pathogen-derived molecular patterns that operates through this protein complex to activate G protein signaling by WNK kinase transphosphorylation of AtRGS1. Because WNK kinases compete for the same substrate, AtRGS1, we hypothesize that activation is sensitive to the AtRGS1 amount and that modulation of the AtRGS1 pool affects the response to the stimulant. Mathematical simulation revealed that the ratio of AtRGS1 to the kinase affects system sensitivity to D-glucose, and therefore illustrates how modulation of the cellular AtRGS1 level is a means to change signal induced activation. AtRGS1 levels change under tested conditions that mimic physiological conditions therefore, we propose is a previously-unknown mechanism by which plants react to changes in their environment.
    關聯: PLoS ONE
    DOI: 10.1371/journal.pone.0190000
    显示于类别:[數學學系暨研究所] 期刊論文

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