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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/112049


    Title: Reclamation of marine chitinous materials for the production of α-glucosdase inhibitors via microbial conversion
    Authors: Van Bon Nguyen;San-Lang Wang
    Keywords: chitin;crab shells;α-glucosidase inhibitor;Paenibacillus;diabetes
    Date: 2017-11-07
    Issue Date: 2017-11-14 02:10:12 (UTC+8)
    Publisher: MDPI
    Abstract: Six kinds of chitinous materials have been used as sole carbon/nitrogen (C/N) sources for producing α-glucosidase inhibitors (aGI) by Paenibacillus sp. TKU042. The aGI productivity was found to be highest in the culture supernatants using demineralized crab shell powder (deCSP) and demineralized shrimp shell powder (deSSP) as the C/N source. The half maximal inhibitory concentration (IC50) and maximum aGI activity of fermented deCSP (38 µg/mL, 98%), deSSP (108 µg/mL, 89%), squid pen powder (SPP) (422 µg/mL, 98%), and shrimp head powder (SHP) (455 µg/mL, 92%) were compared with those of fermented nutrient broth (FNB) (81 µg/mL, 93%) and acarbose (1095 µg/mL, 74%), a commercial antidiabetic drug. The result of the protein/chitin ratio on aGI production showed that the optimal ratio was 0.2/1. Fermented deCSP showed lower IC50 and higher maximum inhibitory activity than those of acarbose against rat intestinal α-glucosidase.
    Relation: Marine Drugs 15(11), p.350(11 pages)
    DOI: 10.3390/md15110350
    Appears in Collections:[Graduate Institute & Department of Chemistry] Journal Article

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