Microwave Assisted Synthesis of Dihydropyrrole by AgOAc Catalyzed Intramolecular Cyclization Reaction of Homopropargyl amine

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Title:	Microwave Assisted Synthesis of Dihydropyrrole by AgOAc Catalyzed Intramolecular Cyclization Reaction of Homopropargyl amine
Authors:	Lee, Adam Shih-Yuan;Lee, Szu-Huio Ma;Chang, Yu-Ting
Keywords:	Homopropargyl amine;Dihydropyrrole;2-Aryl pyrrole;Sonochemical Barbier-type reaction;Microwave irradiation
Date:	2017-06-01
Issue Date:	2017-11-01 02:11:39 (UTC+8)
Publisher:	Springer
Abstract:	A series of 5-aryl dihydropyrrole was synthesized from the intramolecular cyclization reaction of homopropargyl amine in the presence of AgOAc as catalyst under microwave irradiation reaction conditions. The homopropargyl amine was prepared by the reaction of propargyl bromide with N-tosyl aldimine under a sonochemical Barbier-type reaction condition. Further aromatization reaction of 5-aryl dihydropyrrole in KOtBu/DMSO can afford 2-aryl pyrrole under microwave irradiation reaction conditions.
Relation:	Research on Chemical Intermediates 43(6), p.3493–3503
Appears in Collections:	[Graduate Institute & Department of Chemistry] Journal Article

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