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    Title: Mathematical modeling of Interleukin 35 promoting tumor growth and angiogenesis
    Authors: Kang-Ling Liao, Xue-Feng Bai, and Avner Friedman
    Date: 2014-10-30
    Issue Date: 2017-10-25 02:10:47 (UTC+8)
    Abstract: Interleukin-35 (IL-35), a cytokine from the Interleukin-12 cytokine family, has been considered as an anti-inflammatory cytokine which promotes tumor progression and tumor immune evasion. It has also been demonstrated that IL-35 is secreted by regulatory T cells. Recent mouse experiments have shown that IL-35 produced by cancer cells promotes tumor growth via enhancing myeloid cell accumulation and angiogenesis, and reducing the infiltration of activated CD8 T cells into tumor microenvironment. In the present paper we develop a mathematical model based on these experimental results. We include in the model an anti-IL-35 drug as treatment. The extended model (with drug) is used to design protocols of anti-IL-35 injections for treatment of cancer. We find that with a fixed total amount of drug, continuous injection has better efficacy than intermittent injections in reducing the tumor load while the treatment is ongoing. We also find that the percentage of tumor reduction under anti-IL-35 treatment improves when the production of IL-35 by cancer is increased.
    Relation: PLoS One. 2014 Oct 30;9(10):e110126
    DOI: 10.1371/journal.pone.0110126
    Appears in Collections:[Graduate Institute & Department of Mathematics] Journal Article

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