淡江大學機構典藏:Item 987654321/111818
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    題名: The role of CD200-CD200R in tumor immune evasion
    作者: Kang-Ling Liao, Xue-Feng Bai, and Avner Friedman
    關鍵詞: Tumor cells;Macrophages;CD200R;Interleukin 10;Interleukin 12
    日期: 2012-09-01
    上傳時間: 2017-10-25 02:10:42 (UTC+8)
    摘要: CD200 is a cell membrane protein that interacts with CD200 receptor (CD200R) of myeloid lineage cells. During tumor initiation and progression, CD200-positive tumor cells can interact with M1 and M2 macrophages through CD200-CD200R-compex, and downregulate IL-10 and IL-12 productions secreted primarily by M2 and M1 macrophages, respectively. In the tumor microenvironment, IL-10 inhibits the activation of cytotoxic T lymphocytes (CTL), while IL-12 enhances CTL activation. In this paper, we used a system approach to determine the combined effect of CD200-CD200R interaction on tumor proliferation by developing a mathematical model. We demonstrate that blocking CD200 on tumor cells may have opposite effects on tumor proliferation depending on the "affinity" of the macrophages to form the CD200-CD200R-complex with tumor cells. Our results help understanding the complexities of tumor microenvironment.
    關聯: Journal of Theoretical Biology, No. 328, 65-76.
    DOI: 10.1016/j.jtbi.2013.03.017
    顯示於類別:[數學學系暨研究所] 期刊論文

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