The role of CD200-CD200R in tumor immune evasion

機構典藏 > College of Sciences > Graduate Institute & Department of Mathematics > Journal Article > Item 987654321/111818

Please use this identifier to cite or link to this item: https://tkuir.lib.tku.edu.tw/dspace/handle/987654321/111818

Title:	The role of CD200-CD200R in tumor immune evasion
Authors:	Kang-Ling Liao, Xue-Feng Bai, and Avner Friedman
Keywords:	Tumor cells;Macrophages;CD200R;Interleukin 10;Interleukin 12
Date:	2012-09-01
Issue Date:	2017-10-25 02:10:42 (UTC+8)
Abstract:	CD200 is a cell membrane protein that interacts with CD200 receptor (CD200R) of myeloid lineage cells. During tumor initiation and progression, CD200-positive tumor cells can interact with M1 and M2 macrophages through CD200-CD200R-compex, and downregulate IL-10 and IL-12 productions secreted primarily by M2 and M1 macrophages, respectively. In the tumor microenvironment, IL-10 inhibits the activation of cytotoxic T lymphocytes (CTL), while IL-12 enhances CTL activation. In this paper, we used a system approach to determine the combined effect of CD200-CD200R interaction on tumor proliferation by developing a mathematical model. We demonstrate that blocking CD200 on tumor cells may have opposite effects on tumor proliferation depending on the "affinity" of the macrophages to form the CD200-CD200R-complex with tumor cells. Our results help understanding the complexities of tumor microenvironment.
Relation:	Journal of Theoretical Biology, No. 328, 65-76.
DOI:	10.1016/j.jtbi.2013.03.017
Appears in Collections:	[Graduate Institute & Department of Mathematics] Journal Article

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	80	View/Open
index.html		0Kb	HTML	34	View/Open