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    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/111782

    Title: Synthesis of 3-Substituted Indole by AlCl3 Promoted Reaction of α,β-Unsaturated Ketone with Indole
    Authors: Adam Shih-Yuan Lee, Yu-Chi Wu, Yu-Ting Chang and Bo-Cheng
    Keywords: Friedel–Crafts reaction Michael reaction;3-Substituted indole;β,γ-Unsaturated ketone;α,β-Unsaturated ketone
    Date: 2014-06-10
    Issue Date: 2017-10-13 02:10:21 (UTC+8)
    Publisher: Springer
    Abstract: A one-pot Lewis acid-promoted reaction condition of β,γ-unsaturated ketone with indole was developed for the synthesis of 3-substituted indoles with moderate to good yields. A Lewis acid such as AlCl3 was shown to be a promising promoter for in situ isomerization of β,γ-unsaturated ketone to its corresponding α,β-unsaturated ketone, then undergoing Friedel–Crafts Michael addition reaction with indole to afford 3-substituted indole.
    Relation: Research on Chemical Intermediates
    Appears in Collections:[化學學系暨研究所] 期刊論文

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