新型渦流捕捉顆粒晶片之研製

淡江大學機構典藏 > 工學院 > 機械與機電工程學系暨研究所 > 學位論文 > Item 987654321/111406

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题名:	新型渦流捕捉顆粒晶片之研製
其它题名:	New vortex-based flow chips to capture particles
作者:	邱志軒;Ciou, Jhih-syuan
贡献者:	淡江大學機械與機電工程學系碩士班楊龍杰;Yang, Lung-Jieh
关键词:	生物晶片;蜻蜓翼;渦旋;微流道;Biochips;Dragonfly wing;vortex;Microfluidic
日期:	2016
上传时间:	2017-08-24 23:51:59 (UTC+8)
摘要:	本文僅用COSMOL Multiphysics改良了先前新型渦流捕捉顆粒晶片設計，該晶片係將蜻蜓翼與微流道結合在一起，利用蜻蜓翼在流動時會於翅膀皺摺凹陷處產生渦旋之特性，擬於微流道內產生低雷諾數渦旋，進行顆粒之捕捉。本文賦予蜻蜓翼結構實際線寬20μm並模擬不同顆粒大小10μm、20μm之效果，且透過SU-8黃光微影製程，搭配聚二甲基矽氧烷PDMS翻模製程，利用RIE使PDMS與載玻片做結合，成功製作出蜻蜓翼結構之微流道晶片，接著進行微球體灌流實驗，發現在3分鐘後，開始有顆粒吸附；6~9分鐘後，有顆粒阻塞蜻蜓翼微流道情形。根據實驗結果，本文重新定義蜻蜓翼結構在微流道中具有輔助捕捉顆粒之功能，並進一步嘗試結合於Sollier的癌細胞捕捉晶片中，盼望有利於縮小該晶片流道長度。 COMSOL-Multiphysics is used to improve the design of the new vortex-based flow chips to capture particles. With combining the dragonfly-wing microstructure in the flow channel, this flow chip is expected to generate low Reynolds number vortex inside the corrugated grooves, and to trap particles. Not only the particle flow simulation, but also the PDMS flow chips with dragonfly-wing microstructure have been successfully fabricated and tested. The anthor assigned the line width of the dragonfly-wing as 20μm, and the particles sizes as 10 and 20μm. The popular PDMS chip process include the SU-8 photolitnography, PDMS molding, plasma treatment and the glass bonding. The related particle flow feeding experiment reveals that the microbeads begin captured after 3min, and evenmore choke the lower channel undermeath the dragonfly-wing after 6-9min. Based on the expenmental observation, the anthor re-define the function of the dragonfly-wing flow channel, and would combine it to work together with Sollier’s tumor cell capture chp. The goal is to reduce the Sollier’s chip size by the vortex-based dragonfly wing herein.
显示于类别:	[機械與機電工程學系暨研究所] 學位論文

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