| 摘要: | 本研究針對隅角開放型青光眼的生成與發病機制建立出完整的數值模型以及進行模擬力學分析探討。隅角開放型青光眼是因為小樑網的病變導致眼睛內房水排出受阻，使眼球前房前端眼壓上升影響到在後房進而導致壓力堆積，後房壓力經由傳遞壓迫到視神經造成視野上的缺陷與模糊。
本研究使用了兩套軟體, 3D繪圖軟體PROE與有限元素法分析軟體ANSYS, 來進行模型的建立與隅角開放型青光眼相關模擬, 此模擬分析可以了解到青光眼內部的壓力分佈情況以及不同杯盤比時應力的聚集之處。
本研究針對了隅角開放型青光眼不同的杯盤比做應力分佈的探討, 針對杯盤比程度0.3-0.7做每個不同模型的研究, 在相同條件下進行分析模擬, 發現凹陷從0.3-0.7為一種集中靠近視神經盤趨勢, 並研究探討每個不同凹陷應力集中之處也不一樣, 也針對不同集中之處的不同數值大小做分析探討。
本研究內容對於隅角開放型青光眼的模擬分析結果, 可以令青光眼之患者更了解自己相關發病情況, 因為杯盤比大小是造成青光眼發病的主要原因之一, 能提供未來醫學上一個資訊與具有參考價值的模擬數據。
This study explores open-angle glaucoma and its Pathogenesis to create the whole Numerical model and Mechanical analysis. Open-angle glaucoma is caused by pathological changes of trabecular meshwork. Intraocular aqueous fluid will be stuck and intraocular pressure will increase in both anterior and posterior chamber. Then, intraocular pressure of posterior chamber diffuses and oppress optic disc, causes the blurring and disability of sight.
This study apply two software, 3D Design software PROE and Finite element method simulation software ANSYS, to create mode and related simulation of open-angle glaucoma. This simulation analysis helps us to understand pressure distribution of glaucoma and where the stress gathers in different Cup-disc ratio.
This study analyzes stress distribution in different Cup-disc ratio of open-angle glaucoma. I do different researches based on Cup-disc ratio degree from 0.3 to 0.7. Under the same condition, I find from degree 0.3 to 0.7, surface depression shows that stress tends to get close to optic disc. Besides, where the stress gathers differs in different surface depression, so I also conduct numerical analysis based on different stress-gathering section.
The result of analyzing open-angle glaucoma can help the patient understand more about the cause of open-angle glaucoma. In addition, because Cup-disc ratio degree is the main cause of open-angle glaucoma, this study can also offer simulated data of reference value in medical use in the future. |
