Dynamics of tumor models and immunotherapy

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Title:	Dynamics of tumor models and immunotherapy
Other Titles:	腫瘤模型的動態行為及其免疫治療
Authors:	陳柏宇;Chen, Po-Yu
Contributors:	淡江大學數學學系碩士班楊定揮;Yang, Ting-Hui
Keywords:	腫瘤模型;免疫療法;Tumor model;Immunotherapy
Date:	2016
Issue Date:	2017-08-24 23:38:51 (UTC+8)
Abstract:	在這工作中，我們考慮KP腫瘤模型的動態系統。首先，非負解是個別奠定無界性和有界性的解的充分條件，然後我們呈現了在使用及不使用免疫療法的無腫瘤平衡解。透過線性系統的局部分析，證明了無腫瘤平衡解的局部穩定性。此外，也研究全域的動態結果。接下來，我們找到正平衡解的存在性的充分條件，不幸的是，還是有可能有其它正平衡解。最後，我們有一些探討生物意義和數值模擬的結果。 In this work, we consider the dynamics of KP tumor model [12]. First, the non-negativity of solutions are showed and sufficient conditions to guarantee the unboundedness and boundedness of solution are established, respectively. Then we present the explicit form of tumor-free equilibrium with or without treatment. By applying local analysis to the linearized system, local stability of the tumor free equilibrium are verified. Moreover, a global dynamical result is also investigated. Next, we find the sufficient condition of the existence of positive equilibria. Unfortunately, there maybe have other positive equilibria. Finally, some biological implications and numerical simulations are presented in the last section.
Appears in Collections:	[Graduate Institute & Department of Mathematics] Thesis

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