English  |  正體中文  |  简体中文  |  Items with full text/Total items : 52068/87197 (60%)
Visitors : 8909103      Online Users : 114
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library & TKU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/110891

    Title: 正子斷層掃描造影劑合成
    Other Titles: Synthesis of potentially positron emission tomography active compounds
    Authors: 林勇宇;Lin, Yung-Yu
    Contributors: 淡江大學化學學系碩士班
    Keywords: 正子斷層掃描;造影藥物;Positron Emission Tomography;18F-NFP;Arginine -Glycine - Aspartic
    Date: 2016
    Issue Date: 2017-08-24 23:38:39 (UTC+8)
    Abstract: 正子斷層掃描造影是一種核子醫學檢驗技術,目前正子斷層掃描造影可用於觀察細胞代謝、蛋白質的合成和神經傳遞功能,診斷腫瘤、心血管、神經與精神性疾病,並給予正確的治療方法。另外,為使正子斷層掃描造影成像更為精準,必須根據檢測部位給予相對的造影藥物,因此造影的藥物在開發及研究是此造影技術相當重要的環節。
    整合素αvβ3受體存在於新生血管内皮细胞和多種腫瘤细胞表面,在血管生成中扮演著關鍵的角色,而精氨酸-甘氨酸-天冬氨酸(Arg-Gly-Asp,RGD)肽可以與整合素αvβ3結合,並具有專一性。因此,我們設計與合成非放射性藥物的4-nitrophenyl-2-fluoropropionate ( NFP )化合物來做為合成氟-18的4-nitrophenyl-
    本論文中,第一部份利用亞硫醯氯來製備氯化醯氯,在與醇反應而得到目標產物。第二部分則是利用1-(3-Dimethylaminopropyl)-3-ethyl-carbodiimide ( EDC )和N, N''-Dicyclohexylcarbodiimide ( DCC )進行酯化反應,而得到目標產物。
    The Positron Emission Tomography (PET) is a nuclear medical inspection technology. Recently, it was further applied to observe the cell metabolism, protein synthesis and psychiatric diseases and to find out proper treatments for some diseases.
    Making PET more accurate for detecting tumor growth scenario diagnosis, it is widely used PET for tumor imaging technology which is based on normal cells can absorb. glucose and them accumulate to certain level that PET really detects. Thus, PET way play a key role in drugs research and development.
    The integrin avb3 receptor relies on the surface of tumor angiogenesis endothelial cells and the tumor cells. It has been confirmed that the integrin avb3 receptor plays an important role of angiogenesis. Therefore, we design and synthesis non-radiopharmaceutical 4-nitrophenyl-2-bromopropionate (NBP) compound as precursor of radiolabelled 4-nitrophenyl-2-[18F]Fluoropropionate (18F-NFP) compound.
    Both NBP and NFP could be easily synthesized by amidation reaction of
    α-halopropionate with p-nitrophenol by using 1-(3-Dimethylaminopropyl)-
    3-ethyl-carbodiimide ( EDC ) as coupling reagent
    Appears in Collections:[化學學系暨研究所] 學位論文

    Files in This Item:

    File Description SizeFormat

    All items in 機構典藏 are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library & TKU Library IR teams. Copyright ©   - Feedback